Levonorgestrel
(or L-Norgestrel) is a molecule used in hormonal contraceptives
under the family of progestins. Q&A on PLANB.
Plan B - Emergency
Contraception
Emergency contraceptive pills (ECPs),
are an oral drug containing high doses of the same hormones found in
regular oral contraceptive pills, which, when taken after
unprotected sexual intercourse, may prevent pregnancy from occurring.
There are several mechanisms of action by which such drugs may work.
Depending on the time during the menstrual cycle that they are taken,
this drug may inhibit or delay ovulation, inhibit tubal transport of the
ovum or sperm cell, or interfere with fertilization.
In cases where it fails to prevent
fertilization, it may prevent implantation; however, studies into the
method of action of progestin-only ECP have called into question whether
ECPs do actually disrupt or prevent implantation.
In this respect, emergency
contraceptive pills work by triggering the same hormonal changes in the
body as regular birth control pills or even breastfeeding — but they
require much higher doses and are less effective than ongoing hormonal
contraceptives. |
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The phrase "morning-after pill"
is a misnomer that is falling out of use due to the fact they are
licensed for use up to 72 hours after sexual intercourse. Emergency
contraception or "emergency contraceptive pills" is the phrase
preferred by the medical community. Unlike chemical abortion, emergency
contraception does not end pregnancies and will not harm a developing
embryo. |
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Emergency Contraception
Pills
Types of
Emergency Contraception Pills
Emergency hormonal contraception was available in two main
forms: the original version was the combined or Yuzpe regimen which uses
large doses of both estrogen and progestin taken as two doses at twelve
hour intervals. This technique is believed to be approximately 75%
effective depending on how soon it is taken after unprotected
intercourse. With this regimen being less effective, and causing more
side effects, than the more recently introduced progestin-only method,
specific products have been withdrawn (Preven in the United States
discontinued May 2004, Schering PC4 in the United Kingdom discontinued
October 2001, and Tetragynon in France).
Medical
Information
The progestin-only method uses the progestin levonorgestrel in a dose of
1.5 mg, either as two 750 μg doses 12 hours apart, or more recently, as
a single dose. This method is now known to be more effective (up to 89%)
and better tolerated (less nausea or vomiting) than the Yupze method
[2], and is available in the U.S. and Canada as Plan B, in the UK as
Levonelle, and in France as NorLevo.
"Dedicated products" such as Plan B and Levonelle are
specifically designed and marketed as emergency contraceptive pills. It
is also possible to obtain the same dosage of hormones, and therefore
the same effect, by taking a number of regular progestin-only or
combined estrogen-progestin oral contraceptive pills.
Side effects of
Emergency Contraception Pills
The most common side effect of emergency contraception pills are nausea,
abdominal pain, fatigue, headache, dizziness, vomiting, and breast
tenderness. These side effects are normally resolved within 24 hours.
The rate of these effects occurring is less for progestin-only pills
when compared to combined pills.
Also common is temporary disruption of the menstrual cycle, which may
manifest as early or late periods, spotting or breakthrough-bleeding,
and (less commonly) missed periods. The primary mechanism of EC is
delaying ovulation. Menstruation occurs on average 14 days after
ovulation, so a delayed ovulation will result in a delayed menstruation.
Suppression of ovulation may cause anovulatory bleeding, which could
manifest as an early period. |
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Source: Press Releases - Wikipedia, FTC and
other public domain sources and product web sites. We have no
affiliation with any of them.
Plan B®
is a registered trademark of Women's Capital Corporation, a subsidiary of
Duramed Pharmaceuticals, Inc.
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